Synthesis and Tubulin-Binding Properties of Some AC- and ABC-Ring Analogs of Allocolchicine
MG Banwell, JM Cameron, M Corbett, JR Dupuche, E Hamel, JN Lambert, CM Lin and MF Mackay
Australian Journal of Chemistry
45(12) 1967 - 1982
Published: 1992
Abstract
Fourteen analogues [compounds (8), (9) and (11)-(22)] of the powerful antimitotic agent allocolchicine (5) have been prepared and evaluated for their ability to prevent tubulin polymerization. The X-ray structure of one of the more active compounds, tricycle (20), is reported.
https://doi.org/10.1071/CH9921967
© CSIRO 1992
