Synthesis of 4,6-Dialkylpyrimidine-5-carbonitriles

Abstract

4,6-Dialkylpyrimidine-5-carbonitriles were synthesized from 2-(1-ethoxyalkylidine)-3-oxoalkane-nitriles and bidentate nucleophiles such as thiourea in the presence of sodium ethoxide. The synthesis was found to be limited to dialkylpyrimidines where both alkyl groups contained between one and three carbons. Subsequent derivatization of the 2-thioxo function provides scope for the synthesis of a variety of novel pyrimidines.