Synthesis of Cyclopropyl Amino Acid Derivatives
CJ Easton, EW Tan and CM Ward
Australian Journal of Chemistry
45(2) 395 - 402
Published: 1992
Abstract
Derivatives of α,β-methanovaline, α,β-methanophenylalanine and β-methyl-αβmethanoalanine have been prepared by regioselective side-chain functionalization of suitably protected amino acid derivatives, followed by cyclization with either sodium hydride or 1,8-diazabicyclo[5.4.O]undec-7-ene. The approach used in this work illustrates a method for the synthesis of cyclopropyl amino acid derivatives which is complementary to existing procedures.
https://doi.org/10.1071/CH9920395
© CSIRO 1992