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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Synthesis of Cyclopropyl Amino Acid Derivatives

CJ Easton, EW Tan and CM Ward

Australian Journal of Chemistry 45(2) 395 - 402
Published: 1992

Abstract

Derivatives of α,β-methanovaline, α,β-methanophenylalanine and β-methyl-αβmethanoalanine have been prepared by regioselective side-chain functionalization of suitably protected amino acid derivatives, followed by cyclization with either sodium hydride or 1,8-diazabicyclo[5.4.O]undec-7-ene. The approach used in this work illustrates a method for the synthesis of cyclopropyl amino acid derivatives which is complementary to existing procedures.

https://doi.org/10.1071/CH9920395

© CSIRO 1992

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