Structural Elucidation of a Novel Scalarane Derivative by Using High-Field (14.1T) N.M.R. Spectroscopy

Abstract

A novel scalarane derivative (2) has been isolated from the marine sponge Carteriospongia foliascens. A complete assignment of the ¹H and ¹³C n.m.r. spectra of (2) was achieved by using cosy-90, ¹H-detected ¹H/¹³C correlation (HMQC sequence) and ¹H-detected long-range ¹H/¹³C correlation (HMBC sequence) experiments, all measured at 600 MHz. The assignment of stereochemistry at C4 was supported by a ROESY spectrum.