Synthesis and Further Ring-Forming Reactions of a New 3-Amino-isoquinoline-4-carbaldehyde

Abstract

The synthesis of 3-amino-6-(p- methylphenoxy )isoquinoline-4-carbaldehyde in two steps from the corresponding ethyl ester is reported. Further ring annulations by Friedlander synthesis are described to give, for example, new tetra- and penta -cyclic systems ( benzo [f] pyrimido [4,5-b][1,8] naphthyridine and benz [f] indolo [3,2-b][1,8] naphthyridine ).