DNA-Binding Compounds. III. Synthesis of a Peptide-Linked Binuclear Platinum(II)-Terpyridine Complex

Abstract

A procedure has been developed for linking two terpyridineplatinum(II), Pt(tpy), chromophores by an oligopeptide chain. It relies on the use of a new reagent, succinimido 3- (triphenylmethylthio)propanoate (2), to acylate the amino end groups of an α,ω-diaminoalkane peptide. Subsequent deprotection of the sulfhydryl groups and coupling with [ (tpy )Pt^lICl ]CI yields the binuclear complexes in good yields. This procedure allowed the synthesis of [ ( tpy )PtS(CH₂)₂ CO-Gly-Gly-Gly-NH(CH₂)₃NHCO-(CH₂)₂SPt(tpy)Cl₂ (5b).