Coriamyrtin and Tutin. A Crystallographic and Conformational Study

Abstract

X-ray analyses have defined the conformational detail of two closely related convulsants, coriamyrtin and tutin. Their structural and pharmacological similarity to picrotoxinin suggest that the three sesquiterpenes act at the same inhibitory synapses and utilize the same binding site. Their geometries, optimized by using AM1 and MacroModel , were found to be consistent with the crystallographic results.