1,2,4-Triazines. 1. The Use of C-13 Nuclear-Magnetic-Resonance Spectroscopy to Determine the Methylation Products of 3-Methylthio-1,2,4-Triazin-5(2h)-One

Abstract

Carbon-13 nuclear magnetic resonance spectroscopy utilizing both proton coupled and decoupled spectra has been found to be a useful method to determine unequivocally the sites of methylation in the 1,2,4-triazine series. Specifically, the method identified the methylation products of 3-methylthio-1,2,4-triazin-5(2H)-one as the new zwitterion 1-methyl-3- methylthio-1,2,4-triazinium-5-olate and the previously reported N², N⁴- and O-methyl isomers.