New quinolinone and bis-quinolinone alkaloids from Euxylophora paraensis

Abstract

Three quinolin-2-one alkaloids were isolated from the heartwood of Euxylophora paraensis andidentified by spectroscopic methods as 2,3,3-trimethyl-2,3,4,5-tetrahydrofurano[3,2-c]quinolin-4-one(2a), its N-methyl derivative (2b), and 3-(1,2-dimethyl-2-hydroxypropyl)-4-hydroxy-1-methylquinolin-2(1 H)-one (3). Four new dimers, E, F, G and B, were also isolated and identified as the bisquinolin-2-ones (5c), (5d), (6) and (9). The unsaturated dimer G and an isomer have been prepared by oxidationof paraensidimerin A and C.