Synthesis of (±)-pluviatolide and (±)-isopluviatolide

Abstract

The structure 2-(4-hydroxy-3-methoxybenzyl)-3-(3,4-methylenedioxybenzyl)-γ-butyrolactonep,r oposed for the dibenzylbutyrolactone lignan pluviatolide, is confirmed by an unequivocal synthesis. The isomer, isopluviatolide (2), has also been synthesized.