Quinazolines. XXV. The synthesis of 8-Chloro-2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine hydrochloride (8-chloroprazosin hydrochloride)

Abstract

A twelve-step synthesis of 8-chloroprazosin (3) hydrochloride starting from vanillin has been achieved in 16% overall yield (59% w/w yield). The hydrochloride is a useful internal standard for the quantitative estimation of the drug prazosin in human plasma.