A ¹⁹⁵Pt and ¹⁵N N.M.R. study of the anticancer drug, cis-diammine-dichloroplatinum(II), and its hydrolysis and oligomerization products

Abstract

¹⁹⁵Pt and ¹⁵N n.m.r, spectra for aqueous solutions of the anti-cancer drug cis-diamminedichloroplatinum(II) and its hydrolysis and oligomerization products are reported. In the blood substituteHanks medium, conversion of cis-[Pt(¹⁵NH₃)₂(H₂0)₂](NO₃)₂ into cis[PtCl₂(¹⁵NH₃)₂], cis-[PtCl(H₂0)(¹⁵NH₃)₂]⁺,[Pt(¹⁵NH₃)₂OH]₃³⁺ and [Pt(¹⁵NH₃)₂OH]₂²⁺ has been observed, the reaction taking several hours at 30ºC. In 0.15 M sodium chloride, both [Pt(NH₃)₂OH]₃³⁺ and[Pt(NH₃)₂OH]₂²⁺ are converted overnight into cis-[PtCl(H₂O)(NH₃)₂]⁺. The infrared bands at 546 and 522 cm^-1 in [Pt(NH₃)₂OH]₂SO₄ and at 520 cm^-1 in [Pt(NH₃)₂OH]₂(SO₄)₃ have been reassigned to Pt-N modes.