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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Copper-catalysed reaction of 2-chloroimidazoles and 2-chlorobenzimidazoles with dimethylamine

CP Whittle

Australian Journal of Chemistry 33(7) 1545 - 1551
Published: 1980

Abstract

The preparation of 2-dimethylamino-benzimidazoles and -imidazoles from the corresponding 2-chloro compounds by reaction with dimethylamine is assisted by the presence of copper salts. In the absence of a copper catalyst, 2-chloroimidazoles fail to react. Kinetic studies indicate a mechanistic relationship to other copper-catalysed reactions for which arylcopper(I) intermediates have been proposed.

https://doi.org/10.1071/CH9801545

© CSIRO 1980

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