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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Temperature and pH dependence of proton N.M.R. of glutamine in peptides

RM Zanacchi and WJ Moore

Australian Journal of Chemistry 33(7) 1505 - 1510
Published: 1980

Abstract

The proton n.m.r. spectra of the peptides Ala-Glu-Gly-Gln-Gly and Gly- Gln-Gly as measured in dimethyl sulfoxide over a range of temperatures yielded kinetic parameters for rotation about the carbon-nitrogen bonds of the glutamine side chains of ΔH 71.6 kJ mol-1, ΔS 2.1 J mol-1 K-1, and ΔH/70.6 kJ mol-1, ΔS -0.5 J mol-1 K-1, respectively, at 298 K. On pH titration in dimethyl sulfoxide/water solutions, the chemical shifts of the cis protons of the glutamine amide remained constant whereas those of the trans protons were altered with a pK corresponding to that of the terminal glycine.

https://doi.org/10.1071/CH9801505

© CSIRO 1980

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