Relationship Between Dipole Moments and Inductive Substituent Constants

Abstract

A linear relationship between μ/d (where μ is the C-X bond dipole moment and d is a distance parameter) and the inductive substituent constant, σ₁ for substituted acetic acids, XCH₂COOH, is derived from a combination of Taft and Kirkwood-Westheimer equations. This linear relationship is similar to the empirical relationship relating μ/d and σ₁, observed in monosubstituted alkanes.