Synthesis of Orthotrithioformates and Related Compounds. Carbanion Formation and Evaluation for 1,4 Addition Reactions with α,β-Unsaturated Ketones

Abstract

The syntheses of potential α-sulfur-substituted carbanion precursors (2a-h) are reported and the results of their subsequent reactions with strong bases are presented. The relatively stable carbanions (3a-d) were made to react with a variety of α,β-unsaturated ketones and the yields of 1,4 and 1,2 addition products were determined.