Direct conversion of α-halo acids into α-halo amides by reaction with 2-phenylazirine

Abstract

Chloro-, bromo-, iodo- and cyano-acetic acids undergo reaction with 2- phenylazirine to afford the highly crystalline 2-chloro-, 2-bromo-, 2- iodo- and 2-cyano-N-phenacylacetamides respectively.