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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Mechanisms for the acetylation of aminopyridines

LW Deady and DC Stillman

Australian Journal of Chemistry 31(8) 1725 - 1730
Published: 1978

Abstract

Rates of acetylation of aminopyridines and some ring methyl-substituted derivatives, with acetic anhydride in acetone at 36°, are reported. The results indicate that rate-determining acetylation is directly at the amino nitrogen for all 2- and 3-aminopyridines studied. Reaction through a ring N-acetyl intermediate occurs for 4-aminopyridine but the presence of a 2-methyl substituent blocks this pathway.

https://doi.org/10.1071/CH9781725

© CSIRO 1978

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