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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Stereoselective and regioselective condensation reactions of coordinated aminoacetone

AR Gainsford and AM Sargeson

Australian Journal of Chemistry 31(8) 1679 - 1688
Published: 1978

Abstract

Treatment of cis-[Co(en)2(NH2CH2R)(NH2CH2COCH3)]3+ ions (R = H, Me, CH2Br, Ph, p-C6H4Cl) with base leads to imine complexes where the coordinated aminoacetone has reacted with a bound monoamine RNH2 or an ethylenediamine moiety. The product distribution appears to be determined by the relative acidity of the monoamine and the ethylenediamine amine centres; condensation is preferred at the most acidic site. Reduction of the imine group in these complexes with BH4- ion leads to new complexes of the type [Co(en)2(NH2CH2CH(Me)NHCH2R)]3+ and [Co(en)(NH2CH2CH2NHCH(Me)CH2NH2)(NH2CH2R)]3+ in which the reduced ligand is synthesized stereospecifically.

https://doi.org/10.1071/CH9781679

© CSIRO 1978

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