Carbocyclic analogues of equol for the immunization of sheep against clover disease. I. Hydroxynaphthalenones

Abstract

Racemic and optical isomers of 7-hydroxy-3-(p-hydroxyphenyl)-3,4- dihydronaphthalen-1(2H)-one (1) have been synthesized and the configurations of the optical isomers assigned by o.r.d. spectrometry. Derivatives of these 3,4-dihydronaphthalen-1(2H)-ones with aminooxyacetic acid were prepared and the 1,2,3,4-tetrahydronaphthalene (24) corresponding to (1) was synthesized.