The total synthesis of (±)-laurinterol and related compounds

Abstract

(±)-Debromolaurinterol acetate (21c) has been synthesized from 2,4- dibromo-5-methoxytoluene by an eight-step sequence which constitutes a formal total synthesis of each of the racemates of laurinterol (1), debromolaurinterol(2), aplysin (3), and debromo-aplysin (4), because of previous interconversions of these sesquiterpenes.