Studies using radioisotopes. III. The biosynthesis of acridone alkaloids

Abstract

The biosynthesis of acridone alkaloids has been investigated in Acronychia baueri and Evodia xanthoxyloides. Anthranilic acid, N- methylanthranilic acid (XI), acetate, and 4-hydroxy-N-methylquinol-2- one (X) are incorporated, and tryptophan appears not to be. Evidence for the existence of (II), (X), (XI), and N-acetylanthranilic acid as metabolites of anthranilic acid in Acronychia baueri is presented. The later, hydroxylation, stages have not yet been clarified.