Insulin peptides. I. Some protected peptides with sequences derived from the A-chain of ovine insulin

Abstract

Syntheses are described of two pentapeptide derivatives with the A_5-9 and A_17-21 sequences, respectively, of ovine insulin, and of a protected tetrapeptide with a modified A_1-4 sequence. Preparation of the three compounds involved the use of the 2,4,6-trimethylbenzyl carboxyl-protecting group in conjunction with the o-nitrophenylsulphenyl and benzyloxycarbonyl amino-protecting groups.