Alkaloids of Crotalaria crispata F. Muell. ex Benth., The Structures of Crispatine and Fulvine

Abstract

Crotalaria crispata F. Muell. ex Benth. contains monocrotaline and two isomeric alkaloids of empirical formula C₁₆H₂₃O₅N. One of these is identical with fulvine, an alkaloid from Crotalaria fulva Roxb., while the other is new and is named crispatine. Fulvine and crispatine are shown to be macrocyclic esters of retronecine with different diastereoisomers of 3-hydroxy-2,3,4-trimethylglutaric acid.