The Formation of 4-Pyridine Methanol from Isonicotinic Acid Hydrazide (Isoniazid) by Mycobacteria

Abstract

4-Pyridine methanol has been isolated and identified as a breakdown product of isonicotinic acid hydrazide (isoniazid) by Mycobacterium tuberculosis B.C.G. The methiodide and hydrochloride mere prepared and analysed and mixed melting points were determined with synthetic 4-pyridine methanol derivatives. Ultraviolet and infrared spectra are shown.