Recent advances in catalysts for the Henry reaction
Xuefei Bao
A B , Xu Li A , Chunfeng Jiang C * , Wei Xiao A * and Guoliang Chen B *
+ Author Affiliations
- Author Affiliations
A Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, China.
B Key Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
C School of Biomedical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi, China.
Xuefei Bao was born in Liaoning, China, and received his PhD in Medicinal Chemistry from Shenyang Pharmaceutical University in 2018. Currently, he is working on his postdoctoral research under the supervision of Professor Guoliang Chen and Dr Wei Xiao in Shenyang Pharmaceutical University. His current research interests are the development of novel bioactive molecules against cancer, stroke and other conditions. |
Guoliang Chen was born in Hunan, China, and received his Master’s degree in Medicinal Chemistry from Shenyang Pharmaceutical University in 1993 and PhD in Medicinal Chemistry from Shenyang Pharmaceutical University in 2005. His current research interests include the development of novel bioactive molecules against cancer, neurodegenerative disease and other conditions. |
Handling Editor: Anastasios Polyzos
Australian Journal of Chemistry 75(10) 806-819 https://doi.org/10.1071/CH22136
Submitted: 14 June 2022 Accepted: 6 September 2022 Published: 8 November 2022
© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing.
Abstract
The Henry reaction, the coupling of a nitro alkane and a carbonyl group, is an important C–C bond-forming reaction giving nitro alkanols, which are useful, versatile intermediates in synthetic organic chemistry and for the pharmaceutical industry. Among the catalysts employed in the Henry reaction, transition metal complex catalysts play an important role. Transition metal complexes, including small molecules and nanoparticles, catalyze the asymmetric Henry reaction efficiently and in most of the cases give chiral nitro alkanol products in good yield and enantiomeric excess. This review summarizes transition metal complex catalysts, metal-free organic catalysts and nanoparticle catalysts for the Henry reaction.
Keywords: catalysis, C–C bond formation, Henry reaction, metal-free organic catalysts, nanoparticle catalysts, nitro alkanols, synthesis, transition metal complexes.
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