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REVIEW
Contents Vol 73(4)

Potential Leptin Receptor Response Modifier Peptides

Laszlo Otvos Jr https://orcid.org/0000-0002-6759-235X A
+ Author Affiliations
- Author Affiliations

A OLPE, LLC, Audubon, PA 19403, USA; Arrevus, Inc., Raleigh, NC 27612, USA; and Institute of Medical Microbiology, Semmelweis University, Budapest 1085, Hungary. Email: laszlootvos@gmail.com




Laszlo Otvos, Ph.D., is the President of OLPE, LLC, a US-based pharmaceutical consulting firm. His main clients are Arrevus, Inc. and Allysta Inc., biotechnology companies that license his adipokine receptor response modifier and host defence peptide patents from Temple University. Dr Otvos is a senior consultant to Arrevus and Allysta. He also serves as an Adjunct Professor for Semmelweis University, Hungary, and Associate Editor for Frontiers in Chemical Biology. Dr Otvos is an author of over 250 peer-reviewed publications with a current h-factor of 63. His main goal is to bring as many peptide drugs to market as possible, either through personal involvement in the preclinical development process or through editorial and public educational activities.

Australian Journal of Chemistry 73(4) 264-270 https://doi.org/10.1071/CH19407
Submitted: 21 August 2019  Accepted: 26 September 2019   Published: 8 November 2019

Abstract

Drug targets for the treatment of obesity and comorbidities represent an ever-renewable source of research opportunities worldwide. One of the earliest is the leptin–leptin receptor system that was discovered in the mid-1990s. Leptin, a satiety hormone, is overproduced in overweight patients but the protein is unable to cross the blood–brain barrier and remains inactive. Circulating high levels of leptin induces a series of conditions that would not be manifested without leptin overproduction, including various forms of cancer and inflammatory and cardiovascular diseases. Current pharmaceutical research focuses on improving the blood–brain barrier penetration of leptin receptor agonists and the development of monofunctional antagonists with broad spectrum therapeutic efficacies but without unwanted side effects. Designer peptides with their expanded chemical space as well as well controllable receptor binding and elimination properties slowly replace full-sized leptin products in the drug development pipeline.


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