Synthesis of Highly Enantio-Enriched Heliespirones A and C by a Diastereoselective Aromatic Claisen Rearrangement
Philip Norcott A and Christopher S. P. McErlean A B
+ Author Affiliations
- Author Affiliations
A School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia.
B Corresponding author. Email: christopher.mcerlean@sydney.edu.au
Australian Journal of Chemistry 71(5) 366-372 https://doi.org/10.1071/CH18019
Submitted: 12 January 2018 Accepted: 7 March 2018 Published: 9 April 2018
Abstract
Computational methods were used to investigate the stereochemical course of the extra-annular Claisen rearrangement. The stereochemical fidelity of the synthetic strategy and comparison of the optical properties support the hypothesis that the heliespirones are scalemic natural products.
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