Anticancer Evaluation of Tris(triazolyl)triazine Derivatives Generated via Click Chemistry
Tamer El Malah A B E , Hany F. Nour B C , A. A. Nayl A , R. A. Elkhashab A , Farouk M. E. Abdel-Megeid B and Mamdouh M. Ali DA Chemistry Department, College of Science, Aljouf University, Skaka 2014, Saudi Arabia.
B Photochemistry Department, National Research Centre, 33 El Buhouth Street, PO Box 12622, Dokki, Giza, Egypt.
C School of Pharmaceutical Science and Technology, Institute for Molecular Design, Tianjin University, Tianjin 300072, China.
D Biochemistry Department, Division of Genetic Engineering and Biotechnology, 33 El Buhouth Street, PO Box 12622, Dokki, Giza, Egypt.
E Corresponding author. Email: tmara_nrc3000@yahoo.com
Australian Journal of Chemistry 69(8) 905-910 https://doi.org/10.1071/CH16006
Submitted: 12 January 2016 Accepted: 26 February 2016 Published: 1 April 2016
Abstract
Click chemistry has been utilised for the preparation of new tris(triazolyl)triazines containing aliphatic and polar side chains through coupling of 2,4,6-triethynyl-[1,3,5]triazines, which possess free terminal alkyne moieties with substituted aromatic azides. The cytotoxic activity and in vitro anticancer potential of the newly synthesised compounds have been evaluated against seven human cancer cell lines including liver HepG2, breast MCF-7, lung A549, acute myeloid leukemia HL-60, colon HCT116, and prostate PC3 cancer cell lines in addition to human normal melanocyte, HFB4. The results revealed that all the compounds did not exhibit any activity against A549, HL-60, and PC3. However compound G2 was effective against MCF-7 and HepG2 cancer cell lines. On the other hand, compound G1a exhibited higher potency against MCF-7 and HepG2 cells with no toxicity on normal cells in comparison with the standard drug doxorubicin.
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