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RESEARCH ARTICLE
Contents Vol 66(6)

Water-Assisted Organocatalysis: An Enantioselective Green Protocol for the Henry Reaction

Prashant B. Thorat A , Santosh V. Goswami A , Wamanrao N. Jadhav A and Sudhakar R. Bhusare A B
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, Dnyanopasak College, Parbhani-431 401, Maharashtra State, India.

B Corresponding author. Email: bhusare71@yahoo.com

Australian Journal of Chemistry 66(6) 661-666 https://doi.org/10.1071/CH12428
Submitted: 19 September 2012  Accepted: 14 March 2013   Published: 5 April 2013

Abstract

We report an enantioselective Henry (nitroaldol) reaction catalysed by an organocatalyst using water as solvent. The enantioselective synthesis of β-nitroalcohols was achieved by using a neutral chiral organocatalyst, through strong hydrogen bonding, which results in the formation of corresponding products in excellent yield and enantioselectivity at room temperature. Other attractive features of the method are the eco-friendly, non-hazardous, and mild reaction conditions, inexpensive catalyst, and simple work up conditions.


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