Continuous Flow Synthesis of Difluoroamine Systems by Direct Fluorination
Christopher B. McPake A , Christopher B. Murray B C and Graham Sandford A C
+ Author Affiliations
- Author Affiliations
A Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
B AWE, Aldermaston, Reading, Berkshire, RG7 4PR, UK.
C Corresponding authors. Email: christopher.murray@awe.co.uk; graham.sandford@durham.ac.uk
Australian Journal of Chemistry 66(2) 145-150 https://doi.org/10.1071/CH12381
Submitted: 15 August 2012 Accepted: 27 September 2012 Published: 17 January 2013
Abstract
Continuous flow methodology for the synthesis of perfluoroaryl difluoroamine derivatives by reaction of fluorine gas with an appropriate perfluoroaniline substrate is described, further demonstrating the efficient use of flow regimes for reactions involving highly reactive and toxic reagents.
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