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RESEARCH ARTICLE
Contents Vol 65(10)

One-Pot, Three-Step Reaction of 5-[(Trimethylsilyl)ethynyl]pyrrolidin-2-one with Azides Catalyzed by CuI: Synthesis of a Novel Class of 1,4-Disubstituted 1,2,3-Triazoles

Hélio A. Stefani A D , Fernando P. Ferreira B and Adriano S. Vieira C
+ Author Affiliations
- Author Affiliations

A Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP – Brazil – CEP 05508-900.

B Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo, SP – Brazil – CEP 04023-062.

C Instituto de Química, Universidade Estadual de Campinas, Campinas, SP – Brazil – CEP 13083-866.

D Corresponding author. Email: hstefani@usp.br

Australian Journal of Chemistry 65(10) 1443-1450 https://doi.org/10.1071/CH12255
Submitted: 23 May 2012  Accepted: 26 July 2012   Published: 31 August 2012

Abstract

A very fast, easy and efficient synthesis is described for a novel and biologically important class of 1,4-disubstituted-4-(5-pyrrolidin-2-one)-1,2,3-triazoles by an ultrasound-assisted one-pot, three-step click reaction sequence of 5-[(trimethylsilyl)ethynyl]pyrrolidin-2-one with organic azides mediated by catalytic CuI salts.


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