The In Vitro and In Vivo Antitumour Activities of Nitrosyl Ruthenium Amine Complexes
Renata Z. Osti A D , Fabiana A. Serrano C D , Thaysa Paschoalin B , Mariana H. S. Massaoka B , Luiz R. Travassos B , Daniela R. Truzzi A , Elaine G. Rodrigues C E and Douglas W. Franco A E F
+ Author Affiliations
- Author Affiliations
A Departamento de Química e Física Molecular, Instituto de Química de São Carlos – Universidade de São Paulo (USP), São Carlos, SP 13560-970, Brazil.
B Unidade de Oncologia Experimental, Disciplina de Biologia Celular, Departamento de Microbiologia, Imunologia e Parasitologia – Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP 04023-062, Brazil.
C Laboratório de Imunobiologia do Cancer, Disciplina de Biologia Celular, Departamento de Microbiologia, Imunologia e Parasitologia – Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP 04023-062, Brazil.
D These two authors contributed equally to this work.
E These two authors contributed equally to this work.
F Corresponding author. Email: douglas@iqsc.usp.br
Australian Journal of Chemistry 65(9) 1333-1341 https://doi.org/10.1071/CH12245
Submitted: 17 May 2012 Accepted: 8 July 2012 Published: 4 September 2012
Abstract
Ruthenium compounds of the type trans-[Ru(NO)(NH3)4(L)]X3, L = N-heterocyclic ligands, P(OEt)3, SO32–, X = BF4– or PF6–, or [Ru(NO)Hedta], were tested for antitumour activity in vitro against murine melanoma and human tumour cells. The ruthenium complexes induced DNA fragmentation and morphological alterations suggestive of necrotic tumour cell death. The calculated IC50 values were lower than 100 μM. Complexes for which L = isn or imN were partially effective in vivo in a syngeneic model of murine melanoma B16F10, increasing animal survival. In addition, the same ruthenium complexes effectively inhibited angiogenesis of HUVEC cells in vitro. The results suggest that these nitrosyl complexes are a promising platform to be explored for the development of novel antitumour agents.
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