Stabilization of Triam(m)inechloridoplatinum Complexes by Oxidation to PtIV
Helen L. Daly A , Matthew D. Hall A , Timothy W. Failes A , Mei Zhang B , Garry J. Foran C and Trevor W. Hambley A D
+ Author Affiliations
- Author Affiliations
A School of Chemistry, The University of Sydney, NSW 2006, Australia.
B Department of Radiation Oncology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
C Australian Synchrotron Research Program, c/- ANSTO, Private Mail Bag 1, Menai, NSW 2234, Australia.
D Corresponding author. Email: trevor.hambley@sydney.edu.au
Australian Journal of Chemistry 64(3) 273-278 https://doi.org/10.1071/CH11041
Submitted: 25 January 2011 Accepted: 20 February 2011 Published: 11 March 2011
Abstract
PtIV analogues of the active end groups {PtClN3} of multinuclear Pt anticancer drugs have been investigated. The crystal structure of trans,mer-[PtCl(OH)2(dien)]Cl shows that the bond lengths are similar to those in the dihydroxidoplatinum(iv) analogue of cisplatin. The axial ligands are shown to be the predominant influence on reduction potentials with the dihydroxido complex trans,mer-[PtCl(OH)2(NH3)3]Cl being the most resistant to reduction. X-ray absorption near-edge spectroscopy is shown to be suitable for monitoring the oxidation state of these complexes and reveals that trans,mer-[PtCl(OH)2(NH3)3]+ survives for more than 2 h in cancer cells.
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