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RESEARCH FRONT
Contents Vol 64(5)

Luminescent Terbium Contrast Agent for Bone Microdamage Detection

Brian K. McMahon A , Peter Mauer A , Colin P. McCoy C , T. Clive Lee B and Thorfinnur Gunnlaugsson A D
+ Author Affiliations
- Author Affiliations

A School of Chemistry, Center for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.

B Department of Anatomy, Royal College of Surgeons in Ireland, St. Stephen’s Green, Dublin 2, Ireland.

C School of Pharmacy, Queen’s University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Ireland.

D Corresponding author. Email: gunnlaut@tcd.ie

Australian Journal of Chemistry 64(5) 600-603 https://doi.org/10.1071/CH11021
Submitted: 13 January 2011  Accepted: 23 March 2011   Published: 30 May 2011

Abstract

The synthesis and photophysical evaluation of a new lanthanide luminescence imaging agent is presented. The agent, a terbium-based cyclen complex can, through the use of an iminodiacetate moiety, bind to damaged bone surface via chelation to exposed Ca(ii) sites, enabling the imaging of the damage using confocal fluorescence scanning microscopy.


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