Australin E Isolated from the Soft Coral Cladiella sp. Collected in Pohnpei Activates the Inositol 5-Phosphatase SHIP1

David E. Williams; Ashraf Amlani; Ariyanti S. Dewi; Brian O. Patrick; Leen van Ofwegen; Alice L.-F. Mui; Raymond J. Andersen

doi:10.1071/CH10053

RESEARCH FRONT

Australin E Isolated from the Soft Coral Cladiella sp. Collected in Pohnpei Activates the Inositol 5-Phosphatase SHIP1

David E. Williams ^A , Ashraf Amlani ^B , Ariyanti S. Dewi ^A , Brian O. Patrick ^A , Leen van Ofwegen ^C , Alice L.-F. Mui ^B and Raymond J. Andersen ^A ^D

+ Author Affiliations

- Author Affiliations

^A Departments of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, B.C. V6T 1Z1, Canada.

^B Department of Surgery, The Jack Bell Research Centre, University of British Columbia, B.C. V6H 3Z6, Canada.

^C National Museum of Natural History, PO Box 9517, 2300 RA Leiden, The Netherlands.

^D Corresponding author. Email: randersn@interchange.ubc.ca

Australian Journal of Chemistry 63(6) 895-900 https://doi.org/10.1071/CH10053
Submitted: 28 January 2010 Accepted: 18 March 2010 Published: 11 June 2010

Abstract

Four new diterpenoids, australins E–H (1–4), have been isolated from the marine soft coral Cladiella sp. collected in Pohnpei. The structures of 1–4 were elucidated by analysis of their NMR and mass spectrometry data combined with an X-ray diffraction analysis of australin E (1). Australin E (1) activates the inositol 5-phosphatase SHIP1 in vitro.

Acknowledgement

Financial support was provided by grants from the National Cancer Institute of Canada, Canadian Institute for Health Research (MOP-84539), and Aquinox Pharmaceuticals to R.J.A. and A.M. R.J.A. thanks Pfizer for the generous gift of marine invertebrate specimens.

References

Australin E Isolated from the Soft Coral Cladiella sp. Collected in Pohnpei Activates the Inositol 5-Phosphatase SHIP1

Abstract

Acknowledgement

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