Synthesis of MUC1 Peptide and Glycopeptide Dendrimers

Candy K. Y. Chun; Richard J. Payne

doi:10.1071/CH09282

RESEARCH FRONT

Previous Next Contents Vol 62(10)

Synthesis of MUC1 Peptide and Glycopeptide Dendrimers

Candy K. Y. Chun ^A and Richard J. Payne ^A ^B

+ Author Affiliations

- Author Affiliations

^A School of Chemistry, The University of Sydney, NSW 2006, Australia.

^B Corresponding author. Email: payne@chem.usyd.edu.au

Australian Journal of Chemistry 62(10) 1339-1343 https://doi.org/10.1071/CH09282
Submitted: 12 May 2009 Accepted: 19 June 2009 Published: 13 October 2009

Abstract

Several dendrimers possessing multiple copies of peptides and glycopeptides belonging to the MUC1 eicosapeptide tandem repeat sequence have been prepared. Fmoc-strategy solid-phase peptide synthesis was used to construct the peptides and glycopeptides, which were conjugated to suitably functionalized dendrimer cores using the copper-catalyzed azide-alkyne cycloaddition reaction to produce multivalent peptide and glycopeptide dendrimers.

Acknowledgements

We would like to thank the Australian Research Council for funding and Yves Hsieh for assistance with MALDI-TOF mass spectrometry.

References

Synthesis of MUC1 Peptide and Glycopeptide Dendrimers

Abstract

Acknowledgements

Subscriber Login