Synthesis and Characterization of Some Metal Complexes of 4,5-Diazafluoren-9-one and their Biological Effects on Human Carcinoma Cells

Guo-Liang Lu; Cheuk-Lam Ho; Qiwei Wang; Wai-Yeung Wong; Chung-Hin Chui; Raymond Siu-Ming Wong; Roberto Gambari; Fung-Yi Lau; Marcus Chun-Wah Yuen; Cindy Sze-Wai Tong; Andrew Kit-Wah Chan; Johnny Cheuk-On Tang; Kwok-Ping Ho; Gregory Yin-Ming Cheng

doi:10.1071/CH08342

RESEARCH ARTICLE

Synthesis and Characterization of Some Metal Complexes of 4,5-Diazafluoren-9-one and their Biological Effects on Human Carcinoma Cells

Guo-Liang Lu ^A , Cheuk-Lam Ho ^A , Qiwei Wang ^A , Wai-Yeung Wong ^A ^E , Chung-Hin Chui ^B ^C , Raymond Siu-Ming Wong ^B , Roberto Gambari ^D , Fung-Yi Lau ^B , Marcus Chun-Wah Yuen ^C , Cindy Sze-Wai Tong ^B ^C , Andrew Kit-Wah Chan ^B ^C , Johnny Cheuk-On Tang ^C , Kwok-Ping Ho ^C ^E and Gregory Yin-Ming Cheng ^B ^E

+ Author Affiliations

- Author Affiliations

^A Department of Chemistry, Hong Kong Baptist University, Waterloo Road, Hong Kong, China.

^B Haematology Division, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

^C Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hunghom, Hong Kong, China.

^D BioPharmaNet, Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy.

^E Corresponding authors. Email: rwywong@hkbu.edu.hk; bckpho@inet.polyu.edu.hk; gcheng@cuhk.edu.hk

Australian Journal of Chemistry 61(12) 975-980 https://doi.org/10.1071/CH08342
Submitted: 10 August 2008 Accepted: 9 October 2008 Published: 10 December 2008

Abstract

Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl₂], [(DAFO)PtCl₂], and [(DAFO)ZnCl₂], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials.

Acknowledgements

Financial support from a Competitive Earmarked Research Grant (CERG) Grant from the Hong Kong Research Grants Council of the Hong Kong SAR, China (Project no. HKBU2021/06P) and Hong Kong Baptist University is gratefully acknowledged (to W.-Y. Wong). We also acknowledge financial support from the Haematology Research Funding, Haematology Division, Department of Medicine and Therapeutics, Prince of Wales Hospital, the Chinese University of Hong Kong, and the internal research grants offered by the Hong Kong Polytechnic University to Dr K.-P. Ho (Grant no. PA3F and 879D). R. Gambari is supported by a grant from Italian Association for Cancer Research (AIRC).

References

Synthesis and Characterization of Some Metal Complexes of 4,5-Diazafluoren-9-one and their Biological Effects on Human Carcinoma Cells

Abstract

Acknowledgements

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