A Simple and Economic Synthesis of Propargylamines by CuI-Catalyzed Three-Component Coupling Reaction with Succinic Acid as Additive

Gerui Ren; Jinli Zhang; Zheng Duan; Mengjun Cui; Yangjie Wu

doi:10.1071/CH08086

RESEARCH ARTICLE

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A Simple and Economic Synthesis of Propargylamines by CuI-Catalyzed Three-Component Coupling Reaction with Succinic Acid as Additive

Gerui Ren ^A , Jinli Zhang ^A , Zheng Duan ^A , Mengjun Cui ^A and Yangjie Wu ^A ^B

+ Author Affiliations

- Author Affiliations

^A Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, China.

^B Corresponding author. Email: wyj@zzu.edu.cn

Australian Journal of Chemistry 62(1) 75-81 https://doi.org/10.1071/CH08086
Submitted: 28 February 2008 Accepted: 2 July 2008 Published: 21 January 2009

Abstract

A practical and efficient method was developed for the synthesis of propargylamines in a one-pot procedure from aldehydes, amines, and alkynes by using CuI as catalyst and succinic acid as additive. By using this protocol, a wide range of propargylamines was obtained in high yields.

Acknowledgements

We are grateful to the National Natural Science Foundation of China (Project 20772114) and the Innovation Fund for Outstanding Scholars of Henan Province (Project 0621001100) for the financial support given to the present research.

References

A Simple and Economic Synthesis of Propargylamines by CuI-Catalyzed Three-Component Coupling Reaction with Succinic Acid as Additive

Abstract

Acknowledgements

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