Synthesis, Characterization, and Antibacterial and Cytotoxic Study of Metal Complexes with Schiff Base Ligands

Lei Shi; Rui-Qin Fang; Jia-Yu Xue; Zhu-Ping Xiao; Shu-Hua Tan; Hai-Liang Zhu

doi:10.1071/CH07408

RESEARCH ARTICLE

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Synthesis, Characterization, and Antibacterial and Cytotoxic Study of Metal Complexes with Schiff Base Ligands

Lei Shi ^A , Rui-Qin Fang ^A , Jia-Yu Xue ^A , Zhu-Ping Xiao ^A , Shu-Hua Tan ^A and Hai-Liang Zhu ^A ^B

+ Author Affiliations

- Author Affiliations

^A State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China.

^B Corresponding author. Email: zhuhl@nju.edu.cn

Australian Journal of Chemistry 61(4) 288-296 https://doi.org/10.1071/CH07408
Submitted: 27 November 2007 Accepted: 28 February 2008 Published: 24 April 2008

Abstract

The synthesis of 16 metal complexes from four Schiff bases prepared from 5-chloro-2-hydroxybenzaldehyde and primary amines has been described. The synthesized Schiff base ligands and their complexes were characterized by elemental analyses, spectroscopic (UV, IR, ¹H and ¹³C NMR, electrospray ionization-mass spectrometry) methods, and magnetic and conductance measurements. Furthermore, complexes 1a, 1b, 3d, 4a, and 4d were characterized by X-ray diffraction analysis. After the structural characterization, all the compounds were tested in vitro for their antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, and Staphylococcus aureus) activities. The cytotoxic activities of the synthesized compounds were evaluated in vitro against human chronic myeloid leukaemia cells (K562) and a human nasopharyngeal epidermoid tumour cell line. The results indicated that most of the complexes showed good cytotoxic activity against human cancer cell lines but weak cytotoxic activity against a human normal cell line (L02). Among the compounds tested, the cobalt complexes 1a, 2a, 3a, and 4a showed the most favourable antibacterial and cytotoxic activities.

Acknowledgements

The work was financed by a grant (Project 30772627) from the National Natural Science Foundation of China.

References

Synthesis, Characterization, and Antibacterial and Cytotoxic Study of Metal Complexes with Schiff Base Ligands

Abstract

Acknowledgements

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