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Recent Advances in Star Polymer Design: Degradability and the Potential for Drug Delivery

James T. Wiltshire ^A and Greg G. Qiao ^A ^B

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^A Polymer Science Group, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

^B Corresponding author. Email: gregghq@unimelb.edu.au

James Wiltshire received his B.Eng. (Hons1) and B.Sc. degrees in 2003 from the University of Melbourne where he then joined the Polymer Science Group as a graduate student under an Australian Postgraduate Award (APA) Scholarship. He is currently completing his Ph.D. under the supervision of Assoc. Prof. Greg Qiao where he is investigating the design and synthesis of novel degradable polymer architectures. His awards include the 2007 Treloar Prize for the best oral presentation at the 29th Australasian Polymer Symposium.

Greg Qiao received his B.Eng. in Polymer Engineering at East China University in 1982 and his Ph.D. at the University of Queensland with Professor Curt Wentrup in 1996 on synthetic organic chemistry. He then served as a Postdoctoral Fellow with Professor David Solomon at the University of Melbourne, when he entered synthetic polymer field in the same year. In 2000, he became the leader for the group due to the retirement of Prof Solomon. He is now an Associate Professor and Reader in the Department of Chemical and Biomolecular Engineering and a Fellow of Australia Chemical Institute (FRACI). His current research interests are in macromolecular architectures, polymeric membranes, and tissue engineering scaffolds.

Australian Journal of Chemistry 60(10) 699-705 https://doi.org/10.1071/CH07128
Submitted: 27 April 2007 Accepted: 22 June 2007 Published: 9 October 2007

Abstract

The use of polymers as drug delivery devices represents an exciting area of development in the biomedical industry. This paper briefly highlights some of the different types of macromolecules that have attracted attention as potential drug delivery devices, with a particular focus on the class of star polymers known as core cross-linked star (CCS) polymers. The ability to control the rate at which encapsulated molecules can be released is an important factor in the design of efficient drug delivery devices. In this regard, several different techniques to incorporate degradable functionality into CCS polymers are examined as a potential means of controlling release kinetics.

References

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