α-Phenylethyl Substituted Bis(pivaloyloxymethyl) Ester Analogues of Fosmidomycin and FR900098

Thomas Kurz; Christoph Behrendt; Uwe Kaula; Bärbel Bergmann; Rolf D. Walter

doi:10.1071/CH07018

RESEARCH ARTICLE

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α-Phenylethyl Substituted Bis(pivaloyloxymethyl) Ester Analogues of Fosmidomycin and FR900098

Thomas Kurz ^A , Christoph Behrendt ^A , Uwe Kaula ^A , Bärbel Bergmann ^B and Rolf D. Walter ^B

+ Author Affiliations

- Author Affiliations

^A Institute of Pharmacy, University of Hamburg, Bundesstraße 45, 20146 Hamburg, Germany.

^B Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Straße 74, D-20359 Hamburg, Germany.

^C Corresponding author. Email: kurz@chemie.uni-hamburg.de

Australian Journal of Chemistry 60(3) 154-158 https://doi.org/10.1071/CH07018
Submitted: 22 January 2007 Accepted: 23 February 2007 Published: 2 April 2007

Abstract

α-Phenylethyl substituted bis(pivaloyloxymethyl) ester analogues of the natural products Fosmidomycin and FR900098 have been synthesized, and their in vitro antimalarial activity determined. The α-phenylethyl substituted Fosmidomycin analogue displays moderate in vitro antimalarial activity against the chloroquine-sensitive strain 3D7 of Plasmodium falciparum.

References

α-Phenylethyl Substituted Bis(pivaloyloxymethyl) Ester Analogues of Fosmidomycin and FR900098

Abstract

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