Optically Encoded Particles and Their Applications in Multiplexed Biomedical Assays

Bronwyn J. Battersby; Matt Trau

doi:10.1071/CH07006

RESEARCH FRONT

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Optically Encoded Particles and Their Applications in Multiplexed Biomedical Assays

Bronwyn J. Battersby ^A and Matt Trau ^A

+ Author Affiliations

- Author Affiliations

^A Centre for Nanotechnology and Biomaterials, Level 5 East, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, QLD 4072, Australia. ;Email: bbattersby@uq.edu.au; m.trau@uq.edu.au

Bronwyn J. Battersby is an NHMRC Industry Fellow within the Australian Institute for Bioengineering & Nanotechnology at the University of Queensland, Australia. Her current research interests include development of novel biosensors and encoding strategies for cancer biomarker discovery, protease screening, and other proteomics and genomics applications. Prior to joining the Centre in 1998, Dr Battersby completed a DAAD Postdoctoral Fellowship at the Technical University of Munich investigating cationic lipid–DNA complexes for gene delivery applications (1997). She received her Ph.D. in colloid and interface chemistry from the University of Queensland in 1994.

Matt Trau is currently Professor of Chemistry and an ARC Federation Fellow at the University of Queensland, Australia. Professor Trau is Director of the Centre for Nanotechnology and Biomaterials and an executive member of the Australian Institiute for Bioengineering and Nanotechnology (AIBN). His main research interests are in the area of nanostructured assembly and manipulation of matter in order to produce novel materials and devices. Applications of this work include novel devices for biomarker discovery, rapid DNA sequencing, diagnostics, drug screening, and novel biomaterials for human implants. Professor Trau obtained his Ph.D. in Physical Chemistry from the University of Melbourne in 1993. Following completion of his Ph.D., he was a Fulbright Research Fellow for four years at Princeton University in the Department of Chemical Engineering and the Princeton Materials Institute. He has also spent time as a visiting Professor at Harvard Medical School, Boston, MA (2000).

Australian Journal of Chemistry 60(5) 343-353 https://doi.org/10.1071/CH07006
Submitted: 10 January 2007 Accepted: 22 March 2007 Published: 28 May 2007

Abstract

In the future, the rapid discovery of new cures, vaccines, and diagnostics for common diseases will depend on the ability of biomedical researchers to investigate complex mixtures of proteins or DNA. The need to measure the abundance of these entities, together with their level of interaction, has driven the development of new research tools that enable simultaneous analysis of multiple analytes (multiplexing). Optically encoded particles are emerging as the multiplexing tools of choice, especially for clinical research. In this Review, an overview of various new optical encoding methods will be presented, together with important biomedical applications in which particle-based assays are currently being used.

Acknowledgments

This work was supported by the Australian Research Council (FF0455861) and the National Health and Medical Research Council (NHMRC Industry Fellowship for BJB-301267). The authors gratefully acknowledge Dr Gwen Lawrie and the Centre for Microscopy and Microanalysis for the transmission electron microscopy. Dr Lawrie is also acknowledged for the optical micrograph showing optical diversity in silica core-shell particles. We acknowledge Kym Ford and Dr Andreas Rühmann for other data included in this Review.

References

Optically Encoded Particles and Their Applications in Multiplexed Biomedical Assays

Abstract

Acknowledgments

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