Nanofibres and their Influence on Cells for Tissue Regeneration

Yanping Karen Wang; Thomas Yong; Seeram Ramakrishna

doi:10.1071/CH05222

RESEARCH FRONT

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Nanofibres and their Influence on Cells for Tissue Regeneration

Yanping Karen Wang ^A , Thomas Yong ^B and Seeram Ramakrishna ^A ^B ^C ^D

+ Author Affiliations

- Author Affiliations

^A Nanoscience and Nanotechnology Initiative, National University of Singapore, Singapore 117576, Singapore.

^B Division of Bioengineering, National University of Singapore, Singapore 117576, Singapore.

^C Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore.

^D Corresponding author. Email: seeram@nus.edu.sg

Karen Wang is a researcher in NUS Nanoscience and Nanotechnology Initiative and has taken part in many projects, especially in the area of tissue engineering using nanofibre scaffolds. She is currently part of the research team ‘Nanofibers Applications for Human Healthcare’, which aims to realize the use of nanofibres in tissue engineering.

ThomasYong is a researcher in the Division of Bioengineering, NUS. Thomas has been involved in projects ranging over molecular and cell biology and more recently in tissue engineering. He is currently part of the research team ‘Nanofibers Applications for Human Healthcare’, and his current aim is to understand the influence of nanofibres on cells and biological systems.

Seeram Ramakrishna is a professor of mechanical engineering and bioengineering at the National University of Singapore and dean of Faculty of Engineering. He is also a board member of the US Defence Science & Technology Agency (DSTA), Temasek Polytechnic Singapore, and the Australian National University, among others. His current research interests are in processing and surface functionalization of electrospun polymer nanofibres and in advancing materials science, manufacturing technology, and design aspects of polymer nanofibres to realize their full potential in medicine, biology, and engineering.

Australian Journal of Chemistry 58(10) 704-712 https://doi.org/10.1071/CH05222
Submitted: 24 August 2005 Accepted: 19 October 2005 Published: 8 November 2005

Abstract

Synthetic polymer and biopolymer nanofibres can be fabricated through self-assembly, phase separation, electrospinning, and mechanical methods. These novel functional biocompatible polymers are very promising for a variety of future biomedical applications. There are many characteristics of nanofibres that would potentially influence cell growth and proliferation. As such, many studies have been carried out to elucidate the cell–nanofibre interaction with the purpose of optimizing the matrix for cell growth and tissue regeneration. In this Review, we present current literatures and our research on the interactions between cells and nanofibres, and the potentials of nanofibre scaffolds for biomedical applications.

References

Nanofibres and their Influence on Cells for Tissue Regeneration

Abstract

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