Synthesis of Methyl 2-Acetamido-2-deoxy-1-seleno-β-d-gluco- and galacto-pyranoside: Selenium Metabolites in Human Urine
Pedro Traar A , Ferdinand Belaj A and Kevin A. Francesconi A BA Institute of Chemistry, Karl-Franzens-University Graz, Universitätsplatz 1, 8010 Graz, Austria.
B Corresponding author. Email: kevin.francesconi@uni-graz.at
Australian Journal of Chemistry 57(11) 1051-1053 https://doi.org/10.1071/CH04176
Submitted: 21 July 2004 Accepted: 25 August 2004 Published: 1 November 2004
Abstract
An efficient synthesis of two methyl 2-acetamido-2-deoxy-1-seleno-β-d-hexopyranosides is reported. The synthesized compounds, which have recently been identified in human urine, will be used in further studies on the metabolism and toxicology of selenium.
Acknowledgments
Olaf Kunert and Klaus Zangger are gratefully thanked for advice on NMR spectroscopy, and Rudolf Pietschnig for measuring 77Se NMR spectra. Doris Kühnelt is thanked for kindly arranging the mass spectrometric data.
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