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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Integrating Structural and Functional Genomics

Lisa Parsons, Fang Liu, Deok Cheon Yeh, Nese Sari and John Orban

Australian Journal of Chemistry 57(7) 619 - 623
Published: 07 July 2004

Abstract

Structural genomics has provided many three-dimensional structures of proteins with unknown or poorly defined function where analysis of the fold suggests a possible binding site for small molecules. An approximate function may be evident from the structure but, most often, the specific target ligand remains unknown. This is a widespread observation in structural genomics programs and demonstrates the limits of structure-based approaches to determining function. Methods to identify the natural target ligands for such proteins, and therefore bridge structural and functional genomics studies, are discussed.

https://doi.org/10.1071/CH04024

© CSIRO 2004

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