The Total Synthesis of (–)-Tetrahydrolipstatin
Jennifer A. Bodkin, Edward J. Humphries and
Malcolm D. McLeod
Australian Journal of Chemistry
56(8) 795 - 803
Published: 18 July 2003
Abstract
Careful control during the bromolactonization of β,γ;-unsaturated acid (4) was required to regioselectively afford the trans-β-lactone (3) as the major diastereomer. Radical debromination of (3) followed by a three-step sequence of reactions afforded the lipase inhibitor (–)-tetrahydrolipstatin (1).https://doi.org/10.1071/CH03121
© CSIRO 2003
