The Synthesis and in Vitro Cytotoxicity of Two trans-Platinum Complexes of Heterocyclic Amines

Abstract

The syntheses and crystal structures of the platinum(II) complexes trans-[PtCl₂(DMSO)(C₄H₉NO)] and trans-[PtCl₂(DMSO)(dmdze)] are described and the mechanisms leading to their formation are discussed. The complex trans-[PtCl₂(DMSO)(C₄H₉NO)] crystallizes in the triclinic space group P1, a 8.1432(8), b 8.5224(8), c 9.0801(9) Å, α 111.780(1), β 91.074(2), γ 98.349(2)°, Z 2, and its structure was refined to an R value of 0.019 on 2470 F. The cytotoxicity of this complex was determined and was found to be lower than that of cisplatin. The complex trans-[PtCl₂(DMSO)(dmdze)] crystallizes in the monoclinic space group C2/c, a 23.498(5), b 8.048(2), c 17.859(6) Å, β 120.88(2), Z 8, and its structure was refined to an R value of 0.034 on 2712 F.