CP-225,917 and CP-263,114 Synthesis Support Studies: Testing a Radical Cyclization Strategy for Installation of the Side-Chains

Abstract

The selenocarbonate (18) has been prepared and shown to react with hexabutyldistannane hydride/allyltributyl-stannane to give, via a radical cyclization/allylation sequence, the lactone (21) embodying vicinal and trans-related functionality likely to be appropriate for elaboration to the side-chains associated with the title compounds (1) and (2) (phomoidrides A and B).