Synthesis of Hippospongic Acid A Analogues Designed for Investigating the Structure-Activity Relationship of its Biological Activity
Yoshikazu Hiraga, Mariko Ago, Munetaka Tokumasu, Ken Kaku and
Katsuo Ohkata
Australian Journal of Chemistry
53(12) 909 - 912
Published: 2000
Abstract
Analogues of hippospongic acid A, which inhibit the gastrulation of sea urchin embryos, were synthesized. From a study on structure—activity relationships, the conjugated carboxylic acid moiety was found to be an essential feature for biological activity.Keywords: Gastrulation; hippospongic acid A; structure— activity relationship; synthesis.
https://doi.org/10.1071/CH00101
© CSIRO 2000
